In the 1950s the evolutionary geneticist, J.B.S. Haldane outlined a serious problem for evolutionary theory. Haldane was not a creationist trying to knock evolutionary theory. He was an evolutionary geneticist. After performing much research and calculations, he reluctantly concluded that many species of higher vertebrates could not plausibly evolve in the available time. The specifics of his research are beyond this short essay but I’ll summarize.
Humans, apes or “human-like creatures”, have generation times of about 20 years and relatively low reproduction rates per individual. If we extrapolate backward to a time 10 million years ago, which is twice as old as the alleged split between gorilla, chimpanzee and man, and if we assume a pace of one trait substitution per generation, a maximum of approximately 500,000 trait substitutions are possible during that time span (i.e. 10 million years divided by one trait every generation of about 20 years). As we learned above, the occurrence of beneficial mutations occurs so rarely, if at all, that assuming one per generation, especially in species with low reproduction rates, is a very generous assumption.
Haldane used a completely unrealistic scenario of 100,000 offspring with a beneficial mutation per generation. What he found was that even with this completely unrealistic scenario, which maximizes evolutionary progress, only about 0.02% of the human genome could be generated in that 10 million year time period. The difference between the DNA of a human and a chimp, our supposed closest living relative, is greater than 5 percent. Considering that this would only account for a negligible amount of the difference between chimp and man (1/250th) in the allotted 10 million years, it becomes obvious that evolution has an obvious problem it cannot explain.
Haldane also determined that over the long term, the average rate of gene substitution is no better than one gene every 300 generations. The implication here is dramatic. Take Haldane’s example of a human-like population with a nominal generation time of 20 years. Given 10 million years, Haldane determined the population could selectively replace a maximum of 1,667 nucleotides (that is 10 million years ÷ 20 years per generation = 500,000 generations, ÷ 300 generations per gene substitution = 1,667). This amounts to one three-hundredths of one one-hundredth of one-percent of the human genome. Obviously changing 1,667 selectively significant nucleotides is not nearly enough to make a human out of an ape, whether in 5 million years or 5 billion years!
Back in the 1960's a few evolutionists tried to challenge Haldane’s findings without success. In the following 50-60 years, and with no real answers, his findings have been largely ignored. In 1993, creationist Walter Remine published a major work which treated the issue in detail.(10) Since its publication, Remine has continued to answer his critics and deal with attempts to confuse the matter by evolutionists (mainly anonymous persons on the internet). However, ReMine claims that Haldane's Dilemma has never been solved, but has rather been “confused, garbled and prematurely brushed aside.”(11)
The important point that Haldane made, and that Remine confirmed and clarified is that the evolutionary origin of organisms with low reproduction rates and long generation times (which includes most 'higher' animals) is impossible, even given the usual millions of years assigned to the history of species on Earth.